Metabolomics analysis based on UHPLC-Q-TOF-MS/MS reveals effects of genistein on reducing mycotoxin citrinin production by Monascus aurantiacus Li AS3.4384
作者： Shanshan He , Xin Liu , Yanling Wang , Jianhua Xie , Heng Gao
DOI: 10.1016/J.LWT.2020.109613
关键词: Chemistry 、 Tricarboxylic acid 、 Metabolomics 、 Metabolic pathway 、 Fermentation 、 Ergosterol 、 Biochemistry 、 Citrinin 、 Monascus 、 Genistein 、 Food science
摘要: Abstract Monascus mold produces useful bioactive compounds such as pigments, monacolin K, and ergosterol. In this study, metabolomics analysis was used to investigate the metabolic profile changes in aurantiacus Li AS3.4384 (MALA) induced by genistein at different fermentation times using UHPLC-Q-TOF-MS/MS. The addition of found not only reduce citrinin but also suppress significant differential metabolites. A total 21 metabolites were involved most pathways (impact >0.1). These affected aspartic acid, glutamic acid pathway, tricarboxylic (TCA) cycle, pyruvate synthesis lysine degradation pathway. Thus, may change precursor for Monascus. findings provide insight into will help improve quality control safety food supplements.
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