作者: Jan Dörr , Andrea Döring , Friedemann Paul
关键词: Cholecalciferol 、 Multiple sclerosis 、 Therapeutic approach 、 Medicine 、 Calcium metabolism 、 Vitamin D and neurology 、 Bioinformatics 、 Neuroprotection 、 Bone remodeling 、 Risk factor 、 Pathology 、 Health policy 、 Drug discovery 、 Biochemistry, medical
摘要: Apart from its principal role in bone metabolism and calcium homeostasis, vitamin D has been attributed additional effects including an immunomodulatory, anti-inflammatory, possibly even neuroprotective capacity which implicates a possible of autoimmune diseases like multiple sclerosis (MS). Indeed, several lines evidence epidemiologic, preclinical, clinical data suggest that reduced levels and/or dysregulation homeostasis is risk factor for the development on one hand, serum are inversely associated with disease activity progression other hand. However, these not undisputable, many questions regarding preventive therapeutic remain to be answered. In particular, available derived interventional trials using supplementation as approach MS inconclusive partly contradictory. this review, we summarise critically evaluate existing link between light crucial question whether optimization status may impact course sclerosis.