Can we prevent or treat multiple sclerosis by individualised vitamin D supply?

作者: Jan Dörr , Andrea Döring , Friedemann Paul

DOI: 10.1186/1878-5085-4-4

关键词: CholecalciferolMultiple sclerosisTherapeutic approachMedicineCalcium metabolismVitamin D and neurologyBioinformaticsNeuroprotectionBone remodelingRisk factorPathologyHealth policyDrug discoveryBiochemistry, medical

摘要: Apart from its principal role in bone metabolism and calcium homeostasis, vitamin D has been attributed additional effects including an immunomodulatory, anti-inflammatory, possibly even neuroprotective capacity which implicates a possible of autoimmune diseases like multiple sclerosis (MS). Indeed, several lines evidence epidemiologic, preclinical, clinical data suggest that reduced levels and/or dysregulation homeostasis is risk factor for the development on one hand, serum are inversely associated with disease activity progression other hand. However, these not undisputable, many questions regarding preventive therapeutic remain to be answered. In particular, available derived interventional trials using supplementation as approach MS inconclusive partly contradictory. this review, we summarise critically evaluate existing link between light crucial question whether optimization status may impact course sclerosis.

参考文章(127)
A. Döring, F. Paul, J. Dörr, Vitamin D und Multiple Sklerose Nervenarzt. ,vol. 84, pp. 173- 189 ,(2013) , 10.1007/S00115-012-3645-Z
Heike A. Bischoff-Ferrari, Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes Advances in Experimental Medicine and Biology. ,vol. 624, pp. 55- 71 ,(2008) , 10.1007/978-0-387-77574-6_5
Steve Simpson, Bruce Taylor, Leigh Blizzard, Anne-Louise Ponsonby, Fotini Pittas, Helen Tremlett, Terence Dwyer, Peter Gies, Ingrid van der Mei, Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Annals of Neurology. ,vol. 68, pp. 193- 203 ,(2010) , 10.1002/ANA.22043
L H Glimcher, E P Amento, A K Bhalla, B Serog, 1,25-dihydroxyvitamin D3 inhibits antigen-induced T cell activation Journal of Immunology. ,vol. 133, pp. 1748- 1754 ,(1984)
Michelino Di Rosa, Michele Malaguarnera, Ferdinando Nicoletti, Lucia Malaguarnera, Vitamin D3: a helpful immuno-modulator Immunology. ,vol. 134, pp. 123- 139 ,(2011) , 10.1111/J.1365-2567.2011.03482.X
Ellen M. Mowry, Lauren B. Krupp, Maria Milazzo, Dorothee Chabas, Jonathan B. Strober, Anita L. Belman, Jamie C. McDonald, Jorge R. Oksenberg, Peter Bacchetti, Emmanuelle Waubant, Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Annals of Neurology. ,vol. 67, pp. 618- 624 ,(2010) , 10.1002/ANA.21972
Sanhong Yu, Margherita T. Cantorna, Epigenetic Reduction in Invariant NKT Cells following In Utero Vitamin D Deficiency in Mice Journal of Immunology. ,vol. 186, pp. 1384- 1390 ,(2011) , 10.4049/JIMMUNOL.1002545
Vanitha A Jagannath, Zbys Fedorowicz, G V Asokan, Edward W Robak, Liz Whamond, Vitamin D for the management of multiple sclerosis Cochrane Database of Systematic Reviews. ,vol. 9, ,(2010) , 10.1002/14651858.CD008422.PUB2
John N Hathcock, Andrew Shao, Reinhold Vieth, Robert Heaney, Risk assessment for vitamin D The American Journal of Clinical Nutrition. ,vol. 85, pp. 6- 18 ,(2007) , 10.1093/AJCN/85.1.6
Season of birth and multiple sclerosis in Sweden Acta Neurologica Scandinavica. ,vol. 121, pp. 20- 23 ,(2010) , 10.1111/J.1600-0404.2010.01396.X