Glycyrrhizin attenuates histamine-mediated MUC5AC upregulation, inflammatory cytokine production, and aquaporin 5 downregulation through suppressing the NF-κB pathway in human nasal epithelial cells.
作者： Haixia Li , Dandan Guo , Liangran Zhang , Xiao Feng
DOI: 10.1016/J.CBI.2018.02.010
关键词: NF-κB 、 Pharmacology 、 Cytokine 、 Histamine 、 Glycyrrhizin 、 Chemistry 、 Inflammation 、 Downregulation and upregulation 、 Interleukin 、 Interleukin 8
摘要: Abstract Allergic rhinitis (AR) is a chronic respiratory inflammatory disease. Glycyrrhizin main bioactive component of the licorice root extract and exhibits anti-inflammatory activity. However, role glycyrrhizin in AR has not been studied. The aim present study was to investigate effect on histamine-induced human nasal epithelial cells (HNEpCs). Here, we found that (20 or 40 μM) inhibited mRNA expression secretion mucin 5 subtype AC (MUC5AC), interleukin (IL)-6 IL-8 HNEpCs. levels aquaporin (AQP5) phosphorylated cyclic adenosine monophosphate-responsive element binding protein (p-CREB) were decreased by histamine HNEpCs increased treated with glycyrrhizin. treatment expressions p-NF-κB p65 p-IκBα HNEpCs, indicating activation NF-κB pathway In addition, inhibition exhibited similar summary, results showed reversed MUC5AC expression, cytokine production, AQP5 involved effect. might be used for complementary alternative therapeutics AR.
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