Desloratadine citrate disodium injection, a potent histamine H(1) receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades.

摘要: Chemokines have chemotactic properties on leukocyte subsets whose modulation plays a pivotal role in allergic inflammatory processes. Our present study was designed to investigate the anti-allergic and anti-inflammatory of desloratadine citrate disodium injection (DLC) elucidate molecular mechanisms its properties. The effects DLC were evaluated based symptoms, serological marker production histological changes nasal mucosa guinea pigs model rhinitis. explored by studying regulation set chemokines extracellular signal-regulated kinase (ERK)1/2 nuclear factor-kappa B (NF-κB) pathways, after treatment rhinitis vivo histamine-activated human epithelial cells (HNECs) vitro. In pigs, alleviated inhibited infiltration lavage fluid (NLF) histamine, monocyte protein (MCP)-1, regulated activation normal T cell expressed, presumably secreted (RANTEs) interleukin (IL)-8 release sera P-ERK1/2 NF-κB mucosa. vitro, markedly histamine-induced MCP-1, RANTEs IL-8 suppressed c-Raf, mitogen-activated protein/extracellular (MEK) ERK1/2 HNECs. These results provide evidence that possesses potent mechanism action underlying inflammation appears be inhibition phosphorylation ERK1/2, addition blocking pathway.