Molecular diagnostics of soft tissue tumors.
作者： Allison M. Cushman-Vokoun , Julia A. Bridge
关键词: Mesenchymal Tumor 、 Pathology 、 Case files 、 Malignant soft tissue tumors 、 Immunohistochemistry 、 Biology 、 Diagnostic tools 、 Molecular diagnostics 、 Soft tissue
摘要: Abstract Context.—Soft tissue pathology encompasses a remarkably diverse assortment of benign and malignant soft tumors. Rendering definitive diagnosis is complicated not only by the large volume existing histologic subtypes (>100) but also frequently presence overlapping clinical, histologic, immunohistochemical, and/or radiographic features. During past 3 decades, mesenchymal tumor–specific, cytogenetic molecular genetic abnormalities have demonstrated an increasingly important, ancillary role in tumor diagnostics. Objectives.—To review diagnostic tools available to pathologist further classify specific types recurrent aberrations examined. Advantages limitations individual approaches will be highlighted. Data Sources.—Previously published articles, peer-reviewed research publications, extensive experience authors include case files The ...
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M. F. Roussel, B. S. Braun, D. N. Shapiro, C. T. Denny, J. N. Davis, In-Sang Jeon, J. E. Sublett, A VARIANT EWING'S SARCOMA TRANSLOCATION (7;22) FUSES THE EWS GENE TO THE ETS GENE ETV1 Oncogene. ,vol. 10, pp. 1229- 1234 ,(1995)
S. Asko-Seljavaara, M. Tarkkanen, S. Knuutila, M. Virolainen, M. L. Larramendy, T. Wiklund, C. Blomqvist, I. Elomaa, Comparative genomic hybridization of malignant fibrous histiocytoma reveals a novel prognostic marker. American Journal of Pathology. ,vol. 151, pp. 1153- 1161 ,(1997)
Daniel Pinkel, Richard Segraves, Damir Sudar, Steven Clark, Ian Poole, David Kowbel, Colin Collins, Wen-Lin Kuo, Chira Chen, Ye Zhai, Shanaz H. Dairkee, Britt-marie Ljung, Joe W. Gray, Donna G. Albertson, High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays Nature Genetics. ,vol. 20, pp. 207- 211 ,(1998) , 10.1038/2524
Christian Touriol, Catherine Greenland, Laurence Lamant, Karen Pulford, Frédéric Bernard, Thérèse Rousset, David Y. Mason, Georges Delsol, Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like). Blood. ,vol. 95, pp. 3204- 3207 ,(2000) , 10.1182/BLOOD.V95.10.3204
Lu Wang, Rohit Bhargava, Tao Zheng, Leonard Wexler, Margaret H. Collins, Diane Roulston, Marc Ladanyi, Undifferentiated Small Round Cell Sarcomas with Rare EWS Gene Fusions: Identification of a Novel EWS-SP3 Fusion and of Additional Cases with the EWS-ETV1 and EWS-FEV Fusions The Journal of Molecular Diagnostics. ,vol. 9, pp. 498- 509 ,(2007) , 10.2353/JMOLDX.2007.070053
Lisa Sarran, Peter Besmer, Ronald P DeMatteo, Sylvia J Tschernyavsky, Marc Ladanyi, Robert Maki, Mark Robson, Elyn Riedel, James M Woodruff, Murray F Brennan, Cristina R Antonescu, Gunhild Sommer, Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors. Clinical Cancer Research. ,vol. 9, pp. 3329- 3337 ,(2003)
Marc Ladanyi, William Gerald, Fusion of the EWS and WT1 Genes in the Desmoplastic Small Round Cell Tumor Cancer Research. ,vol. 54, pp. 2837- 2840 ,(1994)
A Kallioniemi, O. Kallioniemi, D Sudar, D Rutovitz, J. Gray, F Waldman, D Pinkel, Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors Science. ,vol. 258, pp. 818- 821 ,(1992) , 10.1126/SCIENCE.1359641
Stevan R. Knezevich, Deborah E. McFadden, Wen Tao, Jerian F. Lim, Poul H.B. Sorensen, A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma Nature Genetics. ,vol. 18, pp. 184- 187 ,(1998) , 10.1038/NG0298-184
Jerzy Lasota, Anna Jerzak vel Dobosz, Bartosz Wasag, Agnieszka Wozniak, Ewa Kraszewska, Wanda Michej, Konrad Ptaszynski, Piotr Rutkowski, Maarit Sarlomo-Rikala, Sonja E Steigen, Regine Schneider-Stock, Jerzy Stachura, Maria Chosia, Gabriel Ogun, Wlodzimierz Ruka, Janusz A Siedlecki, Markku Miettinen, Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors Laboratory Investigation. ,vol. 87, pp. 1029- 1041 ,(2007) , 10.1038/LABINVEST.3700628