Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like).

摘要: Anaplastic lymphoma kinase (ALK)-positive lymphomas are characterized by expression of a hybrid protein, comprising the cytoplasmic portion ALK tyrosine fused to partner protein. This is often encoded nucleophosmin (NPM) NPM-ALK fusion gene resulting from (2;5)(p23;q35) chromosomal translocation. However, at 2p23 may also be involved in 2 variant translocations, namely t(1;2)(q25;p23) and t(2;3)(p23;q21), which create TPM3-ALK TFG-ALK genes, respectively. We report here with an unusual finely granular staining pattern, clearly different pattern observed ALK-positive carrying or its variants. A cloned complementary DNA sequence 1 these contained second clathrin heavy chain (also referred as polypeptide-like gene) (CLTCL). The distinctive for was likely due binding protein clathrin-coated vesicles. CLTCL constitutively expressed lymphoid cells therefore presumably contributes active promoter CLTCL-ALK gene. had molecular weight (250 kd) that differs all known products, it autophosphorylated vitro assay, confirming hence capable contributing malignant transformation. These cases, therefore, represent hitherto undescribed mechanism activation further illustrate diversity partners