Biochemical and immunopathological changes in experimental neurotoxocariasis

摘要: Abstract Toxocariasis is a widespread soil-transmitted parasitic disease. Toxocara canis larvae migrate through the tissues with special predilection for central nervous system. Recently, neurotoxocariasis being diagnosed in humans increasing frequency due to improved diagnostic tools. The present study aimed at exploring biochemical and immunopathological alterations brain experimental T. infection. For this purpose, 75 -infected mice were sacrificed 2, 5, 16 weeks post-infection. brains removed assayed total larval count, pro-inflammatory cytokines (TNF-α, IL-6), neurotransmitters (γ-aminobutyric acid, glutamate, dopamine, norepinephrine, serotonin). Brain sections also stained histopathological study, assessment of expression inducible nitric oxide synthase (iNOS), glial fibrillary acidic protein (GFAP) by immunohistochemical methods. We found that recovery showed progressive increase over course Furthermore, infected displayed increased iNOS, as well significant disturbances neurotransmitter profile. Astrocytic activation, evidenced enhanced GFAP, was manifest animals. These changes maximal chronic stage infection or intensified time. In conclusion, associated biochemical, immunological, pathological changes.