Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda.
作者： Fred Wabwire-Mangen , Ronald H. Gray , Francis A. Mmiro , Christopher Ndugwa , Carlos Abramowsky
DOI: 10.1097/00126334-199912010-00009
关键词: Immunology 、 Risk factor 、 Chorioamnionitis 、 Acquired immunodeficiency syndrome (AIDS) 、 Placental Membrane 、 Prospective cohort study 、 Immunopathology 、 Population 、 Pregnancy 、 Obstetrics 、 Medicine
摘要: This prospective study was conducted to examine the association between placental membrane inflammation and risks of maternal-to-child (vertical) transmission HIV-1 in Uganda. The cohort consisted 172 HIV-infected pregnant women over 15 years old who presented for antenatal care intended deliver at Mulago Hospital their infants. Data on maternal immune status (CD4 counts or clinical AIDS) concurrent infections with sexually transmitted diseases were obtained. Infants followed-up possible HIV infection using polymerase chain reaction those below months enzyme immunoassay/Western blot infants older than months. Placental villous determined by histopathology. Women without any pathology used as reference group assess vertical rates. Among mother-infant pairs 40 showed evidence giving an overall rate 23.3%. suppression had 11.3% compared 25.5% nonimmunocompromised. immunosuppression a 37.0% rate. Inflammation artificial rupture did not improve rates delivery through cesarean section associated nonsignificant risk reduction. Overall indicates that increases HIV.
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