Perinatal intervention trial in Africa: effect of a birth canal cleansing intervention to prevent HIV transmission

摘要: Abstract Summary Background Perinatal transmission of human immunodeficiency virus (HIV) type 1 contributes significantly to infant mortality. Exposure in the birth canal may account for some transmission. We examined efficacy a washing procedure reducing perinatal Malawi. Methods The infection status infants 3327 control women (conventional delivery procedures) was compared with that 3637 intervention-delivered women. infants' HIV determined by polymerase chain reaction on dried blood spots collected at 6 and 12 weeks age. intervention consisted manual cleansing cotton pad soaked 0·25% chlorhexidine, which done admission labour every 4 h until delivery. Findings No adverse reactions were seen. 2094 (30%) enrolled HIV-infected, 59% their seen follow-up. Among 982 vaginal vertex singleton deliveries HIV-infected women, 269 (27%) infected. had no significant impact rates (27% 505 28% 477 women), except when membranes ruptured more than before (transmission 25% group vs 39% group). Interpretation If exposure is an important risk factor, different or additional methods reduce should be tested. Alternatively, perhaps not major contributor risk.