Perinatal human immunodeficiency virus infection: ruminations on mechanisms of transmission and methods of intervention.

摘要: Perinatal human immunodeficiency virus (HIV) infection is undoubtedly a multifactorial process. Neither the quantity of viremia nor level neutralizing antibody in infected mother alone predictive HIV transmission to her offspring. Additional cofactors may include ability maternal immunity control host cell range and rate viral replication. The placenta probably constitutes an effective barrier unless disrupted by processes such as syphilis. Prevention breaks trophoblast efforts stimulate newborn HIV-specific further decrease perinatal rate.