Down-regulation of MicroRNA-133 predicts poor overall survival and regulates the growth and invasive abilities in glioma
作者： Yu Liu , Lili Han , Yahui Bai , Wei Du , Bo Yang
DOI: 10.1080/21691401.2017.1304551
关键词: Cell biology 、 Forkhead box C1 、 Cell growth 、 Glioma 、 Oncogene 、 Biology 、 Cell culture 、 Downregulation and upregulation 、 microRNA 、 U87
摘要: miRNAs were reported as oncogene or tumour suppressors in various cancers and played important roles development progression. Dysregulated miR-133 has been several cancers, however, the expression biological function of glioma remained unclear. In this study, we found that level was significantly decreased tissues cell lines by RT-qPCR. Then mimics used to evaluate effects on proliferation invasion vitro. We overexpressed could suppress growth, U87 cells. Additionally, forkhead box C1 (FOXC1) tissue it directly regulated miR-133. Overall, study is first proof demonstrate suppressor inhibit invasioned targeting FOXC1, implying a potential therapeutic target for glioma.
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