Lipidic Systems for In Vivo siRNA Delivery
作者： Sherry Y. Wu , Nigel A. J. McMillan
DOI: 10.1208/S12248-009-9140-1
关键词: Computational biology 、 Cell entry 、 Pharmacology 、 Liposome 、 Biology 、 RNA 、 RNA interference 、 Cationic liposome 、 In vivo 、 Small interfering RNA 、 Cell
摘要: The ability of small-interfering RNA (siRNA) to silence specific target genes not only offers a tool study gene function but also represents novel approach for the treatment various human diseases. Its clinical use, however, has been severely hampered by lack delivery these molecules cell populations in vivo due their instability, inefficient entry, and poor pharmacokinetic profile. Various vectors including liposomes, polymers, nanoparticles have thus developed order circumvent problems. This review presents comprehensive overview barriers recent progress both local systemic therapeutic siRNA using lipidic vectors. Different strategies formulating siRNA-loaded lipid particles as well general concern about safe use will be discussed. Finally, current advances targeted impacts on field interference (RNAi)-based therapy presented.
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