Management of Flavobacterium meningitis in the neonates: experience with 18 consecutive cases.

摘要: 18 neonates with bacteriologically confirmed Flavobacterium meningitis and ventriculitis were treated various antibiotic regimens, including the use of intraventricular antibiotics. During course treatment, four patients died. 8/14 developed progressive hydrocephalus which required insertion ventriculo-peritoneal shunts. The remainder 6/14 had normal ventricles or only mild ventriculomegaly. 5/8 5/6 mildly dilated followed up for at least 24 months. 4/5 severe bilateral hearing loss delayed milestones. All 5 although 2 them gross motor delay due to spastic paraplegia. Patients received effective treatment more than 8 days after onset infection while those within infection. Onset ventricular dilatation was associated ventriculitis. Daily ultrasound scanning in early stage helped determine need instillation Combined intravenous rifampicin, moxalactam piperacillin showed promise as an regimen treating ventricles. Once significant ventriculomegaly has occurred, concomitant administration antibiotics, organisms sensitive, necessary eradicate