Synthesis of 7-hydroxy-4-oxo-4H-chromene-and 7-hydroxychroman-2-carboxylic acidN-alkyl amides and their antioxidant activities
作者： Jae-Hwan Kwak , Hae-Eun Kang , Jae-Kyung Jung , Hwajung Kim , Jungsook Cho
DOI: 10.1007/BF02973917
关键词: Stereochemistry 、 Ascorbic acid 、 Side chain 、 Antioxidant 、 Trolox 、 Rat brain 、 Alkyl 、 Pharmacology toxicology 、 Lipid peroxidation 、 Chemistry
摘要: A series of 7-hydroxy-4-oxo-4H-chromene- (3a-h) and 7-hydroxychroman-2-carboxylic acidN-alkyl amides (4a-g) were synthesized their antioxidant activities evaluated. While compounds3a-h less active, compounds4a-g exhibited more potent inhibition lipid peroxidation initiated by Fe2+ ascorbic acid in rat brain homogenates. Among them, acidN-alkylamides (4e-g) bearing nonyl, decyl, undecyl side chain 3 times than trolox (1).
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