Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice
作者： Chaoyun Li , Caroline Zug , Hongchun Qu , Hermann Schluesener , Zhiyuan Zhang
DOI: 10.1016/J.BBR.2014.12.012
关键词: Internal medicine 、 Hesperidin 、 Transforming growth factor beta 、 Transgene 、 Neuropathology 、 Endocrinology 、 Neuroscience 、 Amyloidosis 、 Presenilin 、 Microglia 、 Alzheimer's disease 、 Medicine
摘要: In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly citrus fruits, was orally given (100 mg/kg body weight) 5-month-old transgenic APP/PS1 mice, mouse model of cerebral amyloidosis for disease. After relatively short-term treatment 10 days, hesperidin significantly restored nesting ability social interaction. Further immunohistochemical analysis showed attenuated β-amyloid deposition, plaque associated APP expression, microglial activation TGF-β immunoreactivity brains which suggests that ameliorated behavioral impairments might be attributable reduced Aβ deposition neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects were confirmed vitro. Our findings suggest potential candidate the AD or even other neurodegenerative diseases.
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