Antiallergic activity of hesperidin is activated by intestinal microflora.
作者： Neung-Kee Lee , Seung-Hoon Choi , Sung-Hwan Park , Eun-Kyung Park , Dong-Hyun Kim
DOI: 10.1159/000078083
关键词:
摘要: When hesperidin isolated from pericarpium of Citrus unshiu (family Rutaceae) was incubated with human intestinal microflora, its main metabolite hesperetin, which a in urine orally hesperidin-administered rats. The antiallergic activity and hesperetin were investigated. Hesperidin did not inhibit the histamine release RBL-2H3 cells induced by IgE. However, potently inhibited IgE PCA reaction. inhibitory found to be comparable azelastine, commercially available drug, prostaglandin E2 production lipopolysaccharide-stimulated RAW 264.7 cells. Hesperetin weakly inhibits cyclooxygenase 2 enzyme activities. These results suggest that may prodrug, is metabolized bacteria.
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