Microbiota, Immunoregulatory Old Friends and Psychiatric Disorders

摘要: Regulation of the immune system is an important function gut microbiota. Increasing evidence suggests that modern living conditions cause microbiota to deviate from form it took during human evolution. Contributing factors include loss helminth infections, encountering less microbial biodiversity, and modulation composition by diet antibiotic use. Thus a major mediator hygiene hypothesis (or as we prefer, “Old Friends” mechanism), which describes role organisms with co-evolved, needed be tolerated, crucial inducers immunoregulation. At least partly consequence reduced exposure immunoregulatory Old Friends, many but not all resided in gut, high-income countries are undergoing large increases wide range chronic inflammatory disorders including allergies, autoimmunity bowel diseases. Depression, anxiety stress resilience comorbid these conditions, or can occur individuals persistently raised circulating levels biomarkers inflammation absence clinically apparent peripheral disease. Moreover poorly regulated pregnancy might contribute brain developmental abnormalities underlie some cases autism spectrum schizophrenia. In this chapter explain how drives immunoregulation, faulty immunoregulation predispose psychiatric disease, psychological further via pathways involve We also outline two-way relationship between implicates microbiota, Friends control resilience.