Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents
作者： Saleh I. Alqasoumi , Areej M. Al-Taweel , Ahmed M. Alafeefy , Eman Noaman , Mostafa M. Ghorab
DOI: 10.1016/J.EJMECH.2009.11.021
关键词: Sulfonamide 、 Chemical synthesis 、 Stereochemistry 、 Bicyclic molecule 、 Ehrlich ascites carcinoma 、 Structure–activity relationship 、 Moiety 、 Biological activity 、 Chemistry 、 Doxorubicin
摘要: Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses spectral data. All the target compounds subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24, 19 12 showed higher with IC(50) values (5.5, 6.9, 7 microg/ml) when compared Doxorubicin as a reference drug (IC(50) value 38 microg/ml).
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