Synthesis and in vitro anticancer evaluation of some novel hexahydroquinoline derivatives having a benzenesulfonamide moiety
作者： Mansour S. Al-Said , Mostafa M. Ghorab , Mohammed S. Al-Dosari , Mostafa M. Hamed
DOI: 10.1016/J.EJMECH.2010.11.002
关键词: Docking (molecular) 、 Mechanism of action 、 Chemical synthesis 、 Stereochemistry 、 Bicyclic molecule 、 Carbonic anhydrase 、 Quinoline 、 Moiety 、 Chemistry 、 Active site 、 Organic chemistry 、 Pharmacology 、 Drug discovery 、 General Medicine
摘要: Inhibition of carbonic anhydrase isozymes has been found to have a role in the treatment cancer. Several sulfonamide compounds bearing an aromatic or heteroaromatic ring were posses potent inhibitory activity and so can be used several types In this paper, we present synthesis some novel quinoline 7–13, 21–26, 28 pyrimidoquinoline 14–18, 20, 27 derivatives having moiety. All newly synthesized evaluated for their vitro anticancer activity. showed interesting cytotoxic activities when compared with reference drug. addition, docking into isozyme II (CA II) active site was performed order give suggestion about proposed mechanism action.
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