Treatment of Intracranial Nongerminomatous Germ-cell Tumor by High-dose Chemotherapy and Autologous Stem-cell Rescue

作者: Tsuyoshi Tada , Takeomi Takizawa , Fumi Nakazato , Shigeaki Kobayashi , Kenichi Koike

DOI: 10.1023/A:1006395719917

关键词: GastroenterologyCarcinomaInduction chemotherapyEtoposideAutologous Stem Cell RescueSurgeryMedicinePerformance statusInternal medicineAutologous stem-cell transplantationChemotherapyGerminoma

摘要: Nongerminomatous germ-cell tumor (NGGCT) in the central nervous system (CNS) is still highly lethal. The present study evaluated outcome of high-dose chemotherapy followed by autologous stem-cell rescue (ASCR). patients included three cases choriocarcinoma, two embryonal carcinoma and one case yolk sac carcinoma. High-dose cisplatin (200 mg/m2), etoposide (1250 mg/m2) ACNU (150 were administrated combination with ASCR to at complete remission as a result surgical removal, irradiation, from four seven courses induction chemotherapy. All treated this therapy alive years after diagnosis, living good performance status. have not required any additional treatments ASCR. myelosuppression period, characterized fewer than 500/microl peripheral neutrophils, ranged 8 15 days (median, 11.5 days). Within ASCR, high fever was found patients. Although mild liver dysfunction all patients, renal observed. Hearing disturbance 50% This treatment regime will improve long-term survival for NGGCT.

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