Molecular Determinants of the Prothrombogenic and Inflammatory Phenotype Assumed by the Postischemic Cerebral Microcirculation
作者： Mami Ishikawa , Dianne Cooper , Janice Russell , James W. Salter , John H. Zhang
DOI: 10.1161/01.STR.0000074921.17767.F2
关键词: Pathology 、 Platelet 、 Medicine 、 Intercellular Adhesion Molecule-1 、 Endothelium 、 Selectin 、 Ischemia 、 Microcirculation 、 Platelet adhesiveness 、 Cell adhesion
摘要: Background and Purpose— Circulating blood cells have been implicated in the pathogenesis of cerebral ischemia/reperfusion (I/R) injury stroke. The objective this study was to define magnitude molecular determinants platelet- leukocyte–endothelial cell adhesive interactions induced by I/R mouse brain. Methods— Bilateral common carotid artery occlusion for 1 hour C57BL/6 mice, followed either 40 minutes or 4 hours reperfusion. Fluorescent platelets were administered intravenously, frontal brain surface observed with intravital fluorescence microscopy. Leukocyte–endothelial adhesion monitored use rhodamine-6G. Results— Ischemia reperfusion resulted rolling (125.1±23.6/mm2) firm (109.5±25.8/mm2) leukocytes but not venules. However, reperfusion, (138.8±24.6/mm2) (153.7±22.3/mm2) detected, acc...
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