DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
作者： Ann-Marie Bröske , Lena Vockentanz , Shabnam Kharazi , Matthew R Huska , Elena Mancini
DOI: 10.1038/NG.463
关键词: Molecular biology 、 DNA methyltransferase 、 Biology 、 Epigenetics 、 DNA methylation 、 Reprogramming 、 Multipotent Stem Cell 、 Cell biology 、 Hematopoietic stem cell 、 Stem cell 、 Cellular differentiation
摘要: … To investigate the role of DNA methylation in HSCs, we bred mice in which exons 4 and 5 of Dnmt1 were flanked by loxP sites 12 with mice expressing Cre recombinase under the …
nature.com
ed.ac.uk
mdc-berlin.de
sci-hub.se 参考文章(50)
Steve Dutton, Steve Swindells, A little bit goes a long way ,(2007)
Laurie Jackson-Grusby, Caroline Beard, Richard Possemato, Matthew Tudor, Douglas Fambrough, Györgyi Csankovszki, Jessica Dausman, Peggy Lee, Christopher Wilson, Eric Lander, Rudolf Jaenisch, Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nature Genetics. ,vol. 27, pp. 31- 39 ,(2001) , 10.1038/83730
Colum P. Walsh, J. Richard Chaillet, Timothy H. Bestor, Transcription of IAP endogenous retroviruses is constrained by cytosine methylation Nature Genetics. ,vol. 20, pp. 116- 117 ,(1998) , 10.1038/2413
Jobst Landgrebe, Wolfgang Wurst, Gerhard Welzl, Permutation-validated principal components analysis of microarray data. Genome Biology. ,vol. 3, pp. 1- 11 ,(2002) , 10.1186/GB-2002-3-4-RESEARCH0019
Hui Luo, Qing Li, Julie O'Neal, Friederike Kreisel, Michelle M. Le Beau, Michael H. Tomasson, c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations Blood. ,vol. 106, pp. 2452- 2461 ,(2005) , 10.1182/BLOOD-2005-02-0734
Huafeng Xie, Min Ye, Ru Feng, Thomas Graf, Stepwise Reprogramming of B Cells into Macrophages Cell. ,vol. 117, pp. 663- 676 ,(2004) , 10.1016/S0092-8674(04)00419-2
Rudolf Jaenisch, Adrian Bird, Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nature Genetics. ,vol. 33, pp. 245- 254 ,(2003) , 10.1038/NG1089
Shin-ichi Kaiho, Koji Mizuno, Sensitive assay systems for detection of hemoglobin with 2,7-diaminofluorene: Histochemistry and colorimetry for erythrodifferentiation Analytical Biochemistry. ,vol. 149, pp. 117- 120 ,(1985) , 10.1016/0003-2697(85)90483-X
A Ehlers, E Oker, S Bentink, D Lenze, H Stein, M Hummel, Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype Leukemia. ,vol. 22, pp. 835- 841 ,(2008) , 10.1038/LEU.2008.12
Stefania Bottardi, Alireza Fotouhi Ghiam, François Bergeron, Eric Milot, None, Lineage-specific transcription factors in multipotent hematopoietic progenitors: a little bit goes a long way. Cell Cycle. ,vol. 6, pp. 1035- 1039 ,(2007) , 10.4161/CC.6.9.4208