Innate host barriers to viral trafficking and population diversity: lessons learned from poliovirus.

摘要: Abstract Poliovirus is an error-prone enteric virus spread by the fecal–oral route and rarely invades central nervous system (CNS). However, in rare instances when poliovirus CNS, resulting damage to motor neurons striking often permanent. In prevaccine era, it likely that most individuals within epidemic community were infected; however, only 0.5% of infected developed paralytic poliomyelitis. Paralytic poliomyelitis terrified public initiated a huge research effort, which was rewarded with two outstanding vaccines. During develop vaccines, many questions asked: Why did certain people paralysis? How does move from gut CNS? What limits viral trafficking CNS vast majority individuals? Despite over 100 years research, these remain unanswered. The goal this chapter review our knowledge how moves between hosts, host barriers limit movement, population dynamics impact fitness virulence, offer hypotheses explain incidence disease.