Identification of a Graft-versus-Host Disease-associated human minor Histocompatibility antigen.
作者： J. den Haan , N. Sherman , E Blokland , E Huczko , F Koning
关键词: Epitope 、 Bone marrow 、 Clone (B-cell biology) 、 Cytotoxic T cell 、 Minor histocompatibility antigen 、 Immunology 、 Population 、 Biology 、 Human leukocyte antigen 、 Graft-versus-host disease
摘要: Minor histocompatibility antigen disparities between human leukocyte (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor HA-2 was previously isolated from patient with severe GVHD after HLA-identical transplantation. The HLA-A2.1-bound peptide representing has now been identified. This appears to originate member of non-filament-forming class I myosin family. Because phenotype frequency 95 percent in HLA-A2.1-positive population, it is candidate immunotherapeutic intervention
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