LncRNA UCA1 promotes renal cell carcinoma proliferation through epigenetically repressing p21 expression and negatively regulating miR-495.

摘要: Long non-coding RNAs have recently emerged as important regulators in the pathogenesis and progression of cancers. The long RNA urothelial carcinoma-associated 1 is reportedly upregulated functions an oncogene some tumors. However, role renal cell carcinoma not well elucidated so far. In this study, we found that was overexpressed tissues compared with adjacent normal tissues, higher expression levels were positively associated advanced tumor stage poor survival time patients. Further studies showed knockdown suppressed proliferation S-phase number vitro. Moreover, to be enhancer zeste homolog 2, which p21 through histone methylation (H3K27me3) on promoter. We also increased protein regulating 2. addition, bioinformatics analysis dual-luciferase reporter assays confirmed miR-495 a target carcinoma, promoted by negatively miR-495. These findings illuminated 2 interacted Overall, overexpression may offer novel therapeutic for