Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice.

摘要: The role of costimulation in Ag-induced responses naive and differentiated IL-2 IL-4-producing CD4+ T cells has been examined using from mice expressing a transgenic TCR specific for cytochrome c (81-104) + I-Ek. secretion by pre-activated is dependent on costimulation, because it not induced with chemically fixed APCs significantly inhibited the B7 antagonist, CTLA4-Ig. In contrast, IL-4 vitro Th2-like relatively independent costimulators. Thus, requirement related more to lymphokine profiles than previous activation status lymphocytes.