A ninety-day toxicity study of semicarbazide hydrochloride in Wistar Hannover GALAS rats.

摘要: A ninety-day toxicity study of semicarbazide hydrochloride (SEM-HCl) was conducted in male and female Wistar Hannover GALAS rats fed diet containing the compound at concentration 0, 250, 500 1000 ppm. Suppression body weight gain food consumption found both sexes ppm throughout study. Enlargement deformation knee joints were obvious from week 3, together with thorax tail. Histopathologically, disarrangement chondrocytes fissures cartilage matrix apparent all doses tested epiphyseal articular cartilage. The severity these lesions increased dose-dependently, accompanied by connective tissues bone high doses. Additionally, compact bones became thin, suggesting loss mass. In thoracic aorta, edges elastic laminae rough interlaminar spaces altered a fibrillar to rod or globular appearance. No abnormalities detected any other organs. Taken together, toxicological effects subchronic exposure SEM-HCI mainly observed bone, no-observed-adverse-effect-level estimated present histopathological examination less than 250 sexes.