Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer.
作者： Anthony F. Yu , Jayant Raikhelkar , Emily C. Zabor , Emily S. Tonorezos , Chaya S. Moskowitz
DOI: 10.1155/2016/9363951
关键词: Ejection fraction 、 Systole 、 Cardiotoxicity 、 Stroke volume 、 Pediatrics 、 Cardiology 、 Subclinical infection 、 Medicine 、 Internal medicine 、 Speckle tracking echocardiography 、 Cumulative dose 、 Young adult
摘要: Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis cardiotoxicity. 2DSTE was performed cross-sectional study 134 patients (mean age: 31.4 ± 8.8 years; 55% male; mean time since diagnosis: 15.4 9.4 years) previously treated with anthracyclines cumulative dose: 320 124 mg/m(2)), (n = 52) or without 82) mediastinal radiotherapy. The prevalence LV dysfunction, defined as fractional shortening < 27%, ejection fraction (LVEF) 55%, global longitudinal strain (GLS) ≤ 16%, 5.2%, 6.0%, 23.1%, respectively. Abnormal GLS observed 24 (18%) despite normal LVEF. Indices were similar regardless anthracycline dose. However, worse (18.0 versus 19.0, p 0.003) abnormal higher (36.5% 14.6%, 0.004) Mediastinal radiotherapy associated reduced (p 0.040) after adjusting for sex, age, In adult survivors childhood, adolescent, young cancer, frequently detects dysfunction LVEF be useful long-term cardiac surveillance cancer survivors.
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