Late mortality experience in five-year survivors of childhood and adolescent cancer: The Childhood Cancer Survivor Study
作者： Ann C. Mertens , Yutaka Yasui , Joseph P. Neglia , John D. Potter , Mark E. Nesbit
DOI: 10.1200/JCO.2001.19.13.3163
关键词: Pediatrics 、 Age of onset 、 Cohort study 、 Retrospective cohort study 、 Cohort 、 Population 、 Medicine 、 Cancer 、 Childhood Cancer Survivor Study 、 Cause of death
摘要: PURPOSE: Survivors of childhood and adolescent cancer are at risk for long-term effects disease treatment. The Childhood Cancer Survivor Study assessed overall cause-specific mortality in a retrospective cohort 20,227 5-year survivors. PATIENTS AND METHODS: Eligible subjects were individuals diagnosed with (from 1970 to 1986) before the age 21 who had survived 5 years from diagnosis. Underlying cause death was obtained certificates other sources coded categorized as recurrent disease, sequelae treatment, or non–cancer-related. Age sex standardized ratios (SMRs) calculated using United States population data. RESULTS: cohort, including 208,947 person-years follow-up, demonstrated 10.8-fold excess (95% confidence interval, 10.3 11.3). Risk statistically significantly higher females (SMR = 18.2), 14.0), and...
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