Gamma-glutamyl and beta-aspartyl containing immunomodulator compounds and methods therewith

作者: Andrey S. Simbirtsev , Edward T. Wei , Alexander A. Kolobov

DOI:

关键词: MoleculeBeta (finance)StereochemistryAmino acidMoietyChemistryAlkyl

摘要: Synthetic immunomodulatory molecules having a .gamma.L-glutamyl-, .gamma.D-glutamyl, .beta.-L-aspartyl, or .beta.-D-aspartyl moiety at the amino terminus are provided as illustrated by Formula (A). In (A), "n" is 1 2, R hydrogen, acyl alkyl, and X an aromatic heterocyclic acid its dedvative. A particularly preferred embodiment .gamma.D-glutamyl-L-tryptophan, which has activity.

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