Treatment of metastatic tumors and other conditions

摘要: The present invention generally relates to pharmacology and, in particular, the treatment of tumors and other conditions. In some aspects, is directed subjects having or cancers that are metastatic. Surprisingly, it has been found certain compositions comprising oxidized glutathione-based compounds able effectively treat such by inhibiting cell migration and/or invasion processes, thus, tumor metastases. Without being bound any theory, believed effective since suppress activation critical signaling pathways within cells used for migration, as ErbB2 phosphoinositide-3 kinase (PI3K) pathways, including downstream RhoA AKT pathways. Such regulated ERp5, which a protein disulfide isomerase using redox those unusually sensitive compounds. Thus, composition instant invention, embodiments, surprisingly at preventing While references have disclosed compounds, no reference suggested metastasis, ErbB2, PI3K, RhoA, highly susceptible altering state cell, e.g., Accordingly, use metastases surprising could not be predicted given teachings prior art.