Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production

摘要: A new member of the cyclin family Y (CCNY) is involved in regulation various physiological processes. In this study, role CCNY energy metabolism was characterized. We found that compared with wild-type (WT) mice, Ccny knockout (KO) mice had both lower body weight and fat content. The KO also a higher metabolic rate, resisted stress high-fat diet, were sensitive to calorie restriction. expression levels UCP1 PGC1α significantly brown adipose tissue (BAT) than WT littermate controls, whereas there no significant difference BAT between mice. addition, down-regulation resulted suppression white adipocyte differentiation vivo vitro, while up-regulated by C/EBPα. Furthermore, hepatocytes HepG2 cells depleted insensitive insulin stimulation, consistent inhibition sensitivity liver but changes WAT muscle, indicating regulating hepatic signaling pathway. resistance generated depletion sterol-regulatory element-binding protein (SREBP1) fatty acid synthase (FASN). Together, these results provide link lipid suggest may offer therapeutic approach obesity diabetes.