Heating and eating: brown adipose tissue thermogenesis precedes food ingestion as part of the ultradian basic rest-activity cycle in rats.

摘要: Laboratory rats, throughout the 24 hour day, alternate between behaviorally active and non episodes that Kleitman called basic rest-activity cycle (BRAC). We previously demonstrated brown adipose tissue (BAT), body brain temperatures arterial pressure heart rate increase in an integrated manner during phases. Studies show eating is preceded by increases temperature, but whether into BRAC has not been investigated. In present study of chronically instrumented, unrestrained Sprague-Dawley peaks BAT temperature occurred every 96 ± 7 162 16 min (mean SE, n=14 rats) dark light periods respectively, with no apparent underlying regularity. With food available ad libitum, was a temporally precise manner. Eating only after commencing 15 1 SE) onset increase, difference There were either or weak preprandial postprandial relations intermeal interval amount eaten given meal. Remarkably, rat still disturbed empty container (p>0.05 versus libitum food) at other times. Rather than being triggered changes levels fuels meal-associated factors, sedentary laboratory rats access to commences as part ultradian BRAC, manifestation intrinsic activity.