Use of sulfated cyclofructan 6 and sulfated cyclodextrins for the chiral separation of four basic pharmaceuticals by capillary electrophoresis.
作者： Yi Jun Zhang , Ming Xian Huang , Yu Ping Zhang , Daniel Wayne Armstrong , Zachary S. Breitbach
DOI: 10.1002/CHIR.22206
关键词: Operating voltage 、 Enantiomer 、 Cyclofructan 6 、 Tiropramide 、 Column temperature 、 Chromatography 、 Capillary electrophoresis 、 Chirality (chemistry) 、 Sulfation 、 Chemistry
摘要: Sulfated cyclofructan 6 (S-CF6) and sulfated cyclodextrins (S-α-, β-, γ-CDs) are highly selective chiral selectors for the enantioseparation of basic solutes. In this study, S-CF6 was introduced enantiomeric separation four pharmaceuticals (including tamsulosin, tiropramide, bupivacaine, norephedrine) by capillary electrophoresis (CE), performance compared with S-α-, γ-CDs. The effects selector type, concentration, operating voltage, column temperature were examined optimized. Excellent resolutions obtained all solutes on these selectors. Chirality 25:735–742, 2013. © 2013 Wiley Periodicals, Inc.
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