Combined use of cyclofructans and an amino acid ester‐based ionic liquid for the enantioseparation of huperzine A and coumarin derivatives in CE

摘要: Cyclofructans (CFs) and their derivatives have recently been proven to be efficient chiral selectors (CSs) for the enantioseparation of several analytes in CE, HPLC, GC. In this study, separation ability a number native derivatized CFs was examined CE. Particularly, six different CFs, with derivatization groups cavity sizes [native CF-6 CF-7, isopropyl cyclofructan-6 (IPCF-6), IPCF-7, sulfated (SCF-6), SCF-7] were used as CSs huperzine A, warfarin, coumachlor. Almost all except from SCF-6 & -7, demonstrated relatively low sometimes no A. an effort improve both resolution efficiency, ionic liquid D-Alanine tert butyl ester lactate (D-AlaC4Lac) added into BGE. most cases, combination CF D-AlaC4Lac resulted improvement peak efficiency and/or resolution. When utilized D-AlaC4Lac, 1.4 obtained, while use IPCF-6/D-AlaC4Lac provided baseline enantioseparation. Although SCF-7 40 mM did not affect resolution, it dramatically increased 24,000 117,000. case warfarin coumachlor, IPCF-6 IPCF-7 proved effective CSs. It is, therefore, concluded that size are key parameters capability. is also clear study necessary improved efficiencies resolutions.