Olfactory Receptor Proteins
作者： Guenhaël Sanz , Jean-François Gibrat , Edith Pajot-Augy
DOI: 10.1007/978-94-017-8613-3_3
关键词: Olfactory epithelium 、 Computational biology 、 Transmembrane protein 、 Integral membrane protein 、 Olfactory system 、 Biology 、 Virtual screening 、 G protein 、 G protein-coupled receptor 、 Olfactory receptor
摘要: Bioelectronic noses can utilize olfactory receptors (ORs) as recognition elements. This chapter describes biochemical characteristics of these OR proteins. ORs being G protein-coupled (GPCRs) are integral membrane proteins composed seven transmembrane spanning helices. In mammals, there exist many 1,000 genes accounting for about 3 % the genome. Unfortunately, no three-dimensional (3D) structure is available and one must infer properties from those better characterized GPCRs. The offers a brief overview known 3D structures complexes GPCRs with various types ligands (agonists, inverse agonists, antagonists, etc.) and, in case, also protein. Based on structural data, it then reviews hypotheses experiments regarding GPCR transduction mechanism. how set (17 different to date) be used model that will subsequently platform ligand virtual screening. following section examines mechanisms regulate activity. Lastly, we focus use bioelectronic noses.
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