MLL histone methylases in gene expression, hormone signaling and cell cycle

摘要: Histone methyl-transferases (HMTs) are key enzymes that post-translationally methylate nuclear histone proteins and play critical roles in gene expression, epigenetic regulation diseases eukaryotic organisms. Mixed lineage leukemias (MLLs) human HMTs specifically H3 at lyisine-4 regulate activation. MLLs also well known to be rearranged often acute myeloid lymphoid leukemias. Human encodes several have similar enzymatic activities but diverse functions. Herein, we reviewed the recent advances understanding functions of MLL family regulation, hormone signaling cell cycle human.