Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13.
作者： Khairul I. Ansari , Sahba Kasiri , Imran Hussain , Subhrangsu S. Mandal
DOI: 10.1111/J.1742-4658.2009.07453.X
关键词:
摘要: HOXC13, a homeobox-containing gene, is involved in hair development and human leukemia. The regulatory mechanism that drives HOXC13 expression mostly unknown. Our studies have demonstrated transcriptionally activated by the steroid hormone estrogen (17β-estradiol; E2). promoter contains several estrogen-response elements (EREs), including ERE1 ERE2, which are close to transcription start site, associated with E2-mediated activation of HOXC13. Knockdown receptors (ERs) ERα ERβ suppressed Similarly, knockdown mixed lineage leukemia histone methylase (MLL)3 E2-induced MLLs (MLL1–MLL4) were bound an E2-dependent manner. either or affected binding into EREs, suggesting critical roles ERs recruiting promoter. Overall, our regulated E2 MLLs, which, coordination ERβ, play this process. Although known regulate HOX genes, hormone-mediated regulation genes Herein, we players gene.
sci-hub.se 参考文章(51)
Khairul I Ansari, Bibhu P Mishra, Subhrangsu S Mandal, MLL histone methylases in gene expression, hormone signaling and cell cycle Frontiers in Bioscience. ,vol. Volume, pp. 3483- 3495 ,(2009) , 10.2741/3466
Bibhu P. Mishra, Khairul I. Ansari, Subhrangsu S. Mandal, Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle FEBS Journal. ,vol. 276, pp. 1629- 1640 ,(2009) , 10.1111/J.1742-4658.2009.06895.X
Andrew J Bannister, Tony Kouzarides, Histone Methylation: Recognizing the Methyl Mark Chromatin and Chromatin Remodeling Enzymes, Part B. ,vol. 376, pp. 269- 288 ,(2003) , 10.1016/S0076-6879(03)76018-2
Ann E Drummond, The role of steroids in follicular growth. Reproductive Biology and Endocrinology. ,vol. 4, pp. 16- 16 ,(2006) , 10.1186/1477-7827-4-16
Jerome F. Strauss, Federico Martinez, Marianthi Kiriakidou, Placental steroid hormone synthesis: unique features and unanswered questions. Biology of Reproduction. ,vol. 54, pp. 303- 311 ,(1996) , 10.1095/BIOLREPROD54.2.303
Rigen Mo, Sambasiva M. Rao, Yi-Jun Zhu, Identification of the MLL2 Complex as a Coactivator for Estrogen Receptor α Journal of Biological Chemistry. ,vol. 281, pp. 15714- 15720 ,(2006) , 10.1074/JBC.M513245200
Toshiyuki Yamada, Takeshi Shimizu, Mitsuhiro Suzuki, Fumiko Kihara-Negishi, Naoki Nanashima, Takuya Sakurai, Yang Fan, Miki Akita, Tsuneyuki Oikawa, Shigeki Tsuchida, Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells. Experimental Cell Research. ,vol. 314, pp. 847- 858 ,(2008) , 10.1016/J.YEXCR.2007.11.005
Jay L. Hess, MLL: a histone methyltransferase disrupted in leukemia Trends in Molecular Medicine. ,vol. 10, pp. 500- 507 ,(2004) , 10.1016/J.MOLMED.2004.08.005
Nevan J. Krogan, Jim Dover, Shahram Khorrami, Jack F. Greenblatt, Jessica Schneider, Mark Johnston, Ali Shilatifard, COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. Journal of Biological Chemistry. ,vol. 277, pp. 10753- 10755 ,(2002) , 10.1074/JBC.C200023200
Craig G. Moneypenny, Jing Shao, Yanyu Song, Evan P. Gallagher, MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells Carcinogenesis. ,vol. 27, pp. 874- 881 ,(2006) , 10.1093/CARCIN/BGI322