Inhibitory action of 5-hydroxytryptamine on propulsive activity of the guinea-pig isolated colon
作者： Mitsuo Ishizawa
DOI: 10.1016/0742-8413(96)00010-2
关键词: Endocrinology 、 Circular muscle 、 Tetrodotoxin 、 Endogeny 、 Guinea pig 、 Inhibitory postsynaptic potential 、 Receptor 、 Receptor subtype 、 Internal medicine 、 Biology 、 Inhibitory neurotransmitter 、 Immunology 、 Pharmacology
摘要: Abstract The effects of 5-hydroxytryptamine (5-HT) and its receptor subtype agonists on spontaneous propulsive activities the segment, changes in tension muscle strips were examined guinea-pig isolated distal colon. 5-HT, 5-carboxamidotryptamine (5-CT), α-methyl-5-HT t-methoxytryptamine (5-MeOH), applied to serosal side inhibited activities, but 2-methyl-5-HT did not. On indomethacin-treated 5-HT all stimulated activity. 5-CT, 5-MeOH relaxed circular strips, which presence tetrodotoxin. However, these showed contractile strips. These results suggest that may inhibit colonic segment via release endogenous PGs (e.g., E I types) cells mediated by an inhibitory neurotransmitter, was 1 -like 2 ; 4 receptors myenteric neurones layer.
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