5‐HT1‐like receptors requiring functional cyclo‐oxygenase and 5‐HT2 receptors independent of cyclo‐oxygenase mediate contraction of the human umbilical artery
作者： S.J. MacLennan , M.J. Whittle , J.C. McGrath
DOI: 10.1111/J.1476-5381.1989.TB12033.X
关键词:
摘要: 1. The interactions between 5-hydroxytryptamine (5-HT) and the antagonists ketanserin, methysergide phentolamine were studied in isolated preparations of human umbilical artery (HUA) at physiological oxygen tension (Po2 approximately 15 mmHg) high PO2 (approximately 120 mmHg). 2. At Po2 behaved as silent competitive 5-HT-induced contraction HUA. pA2 values calculated by Schild analysis 8.92, 8.52 6.37, respectively. 3. Po2, contractions antagonised a biphasic manner ketanserin (0.1 microM); response to low but not concentrations 5-HT was resistant blockade ketanserin. ketanserin-resistant component abolished following cyclo-oxygenase inhibition indomethacin (1 microM). 4. partial agonist. Methysergide-induced inhibited indomethacin, 5-HT2 receptor alpha 1-adrenoceptor blockade. 5. mediated mimicked selective 5-HT1-like agonist 5-carboxamidotryptamine (5-CT): 5-CT 7 fold more potent than 5-HT. 6. 2-adrenoceptor antagonist Wy 26703. 7. These results suggest that (i) receptors almost exclusively mediate induced 5-HT, (ii) potency order greater suggests responses are which require functional cyclo-oxygenase.
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