Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation.
作者： Ying Yin , Yue Guan , Jialin Duan , Guo Wei , Yanrong Zhu
DOI: 10.1016/J.EJPHAR.2012.11.005
关键词: TUNEL assay 、 PI3K/AKT/mTOR pathway 、 Terminal deoxynucleotidyl transferase 、 Protein kinase B 、 Biochemistry 、 Pharmacology 、 Wortmannin 、 Reperfusion injury 、 Cardioprotection 、 Medicine 、 Salvia miltiorrhiza
摘要: … cardiomyocytes apoptosis, which were evidenced by increased infarct size, CK-MB, cTnI releases in serum and LDH … size, cell viability loss, and CK-MB, cTnI, LDH activities. The anti-…
sci-hub.se 参考文章(39)
Giora Z. Feuerstein, Apoptosis--new opportunities for novel therapeutics for heart diseases. Cardiovascular Drugs and Therapy. ,vol. 15, pp. 547- 551 ,(2001) , 10.1023/A:1013775906652
Fang Wang, Yu-Ying Liu, Lian-Yi Liu, Qing-Jiang Zeng, Chuan-She Wang, Kai Sun, Ji-Ying Yang, Jun Guo, Jing-Yu Fan, Jing-Yan Han, The attenuation effect of 3,4-dihydroxy-phenyl lactic acid and salvianolic acid B on venular thrombosis induced in rat mesentery by photochemical reaction. Clinical Hemorheology and Microcirculation. ,vol. 42, pp. 7- 18 ,(2009) , 10.3233/CH-2009-1180
Yong Chun Jin, Chun Wook Kim, Young Min Kim, Irina Tsoy Nizamutdinova, Yu Mi Ha, Hye Jung Kim, Han Geuk Seo, Kun Ho Son, Su Jin Jeon, Sam Sik Kang, Yeong Shik Kim, Sung-Chul Kam, Jea Heun Lee, Ki Churl Chang, Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-α-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo. European Journal of Pharmacology. ,vol. 614, pp. 91- 97 ,(2009) , 10.1016/J.EJPHAR.2009.04.038
Dinender Kumar, Lorrie A. Kirshenbaum, Timao Li, Igor Danelisen, Pawan K. Singal, Apoptosis in Adriamycin Cardiomyopathy and Its Modulation by Probucol Antioxidants & Redox Signaling. ,vol. 3, pp. 135- 145 ,(2001) , 10.1089/152308601750100641
Jiajia Fu, Heqing Huang, Jiajun Liu, Rongbiao Pi, Jianwen Chen, Peiqing Liu, Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis. European Journal of Pharmacology. ,vol. 568, pp. 213- 221 ,(2007) , 10.1016/J.EJPHAR.2007.04.031
Antti Saraste, Kari Pulkki, Markku Kallajoki, Kenth Henriksen, Martti Parvinen, Liisa-Maria Voipio-Pulkki, Apoptosis in Human Acute Myocardial Infarction Circulation. ,vol. 95, pp. 320- 323 ,(1997) , 10.1161/01.CIR.95.2.320
Carolyn J. Mullonkal, Luis H. Toledo-Pereyra, Akt in Ischemia and Reperfusion Journal of Investigative Surgery. ,vol. 20, pp. 195- 203 ,(2007) , 10.1080/08941930701366471
Susumu Nishikawa, Tetsuya Tatsumi, Jun Shiraishi, Shinsaku Matsunaga, Mitsuo Takeda, Akiko Mano, Miyuki Kobara, Natsuya Keira, Mitsuhiko Okigaki, Tomosaburo Takahashi, Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis. Journal of Molecular and Cellular Cardiology. ,vol. 40, pp. 510- 519 ,(2006) , 10.1016/J.YJMCC.2006.01.020
Jun-Qiu Song, Xu Teng, Yan Cai, Chao-Shu Tang, Yong-Fen Qi, Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis. ,vol. 14, pp. 1299- 1307 ,(2009) , 10.1007/S10495-009-0398-7
Guang-De Yang, Hui Zhang, Rong Lin, Wei-Rong Wang, Xiao-Lian Shi, Yu Liu, Qiao-Li Ji, Down‐Regulation of CD40 Gene Expression and Inhibition of Apoptosis with Danshensu in Endothelial Cells Basic & Clinical Pharmacology & Toxicology. ,vol. 104, pp. 87- 92 ,(2009) , 10.1111/J.1742-7843.2008.00342.X