Effects of TCF7L2 polymorphisms on obesity in European populations
作者： Stéphane Cauchi , Hélène Choquet , Ruth Gutiérrez-Aguilar , Frédéric Capel , Katrine Grau
DOI: 10.1038/OBY.2007.77
关键词: Odds ratio 、 Population 、 TCF7L2 、 Type 2 diabetes 、 Endocrinology 、 Allele 、 Obesity 、 Adipose tissue 、 Internal medicine 、 Medicine 、 Case-control study
摘要: The transcription factor 7-like 2 (TCF7L2) rs7903146 T allele was previously associated with type diabetes (T2D) and decreased BMI whereas haplotypes carrying the C rs10885406 A alleles (HapA) were increased BMI. functional relevance of TCF7L2 polymorphisms their effects on T2D obesity remained to be further investigated. In white European populations, we found that more in 3,547 non-obese individuals (odds ratio (OR) = 1.88 (1.69-2.10)) than 1,110 class III obese subjects (OR 1.24 (1.03-1.50)). No direct effect HapA any form 3,507 normal glucose tolerant (NGT) individuals, 1,106 pedigrees familial 5,512 from French general population. However, subjects, less prevalent 1,111 (55.2%) compared 659 (67.5% OR 1.69 (1.46-1.95)). Functional studies showed is prone bound by protein factors 3T3-L1, HepG2 beta-TC3 cell lines expression decreases subcutaneous adipose tissue NGT T/T carriers under calorie restriction. conclusion, not a risk for but its modulated obesity. Furthermore, our data suggest may possibly nominal decrease
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