Review of methodology for the determination of macrocyclic lactone residues in biological matrices.

摘要: The macrocyclic lactones (MLs) are probably the anti-parasitic agents most widely used in treatment of food producing animals, poultry, aquaculture and crops. Ivermectin was first lactone product to be licensed for use about 20 years ago. A number alternative products such abamectin, doramectin, emamectin, eprinomectin, moxidectin, milbemycin selamectin, have been marketed since. Because increase ML drugs, there has a steady published analytical methods determination their residues. In this paper, structure properties different drugs available on market described. occurrence persistence residues is discussed relation marker current maximum residue limits (MRLs) as defined European Union (EU). Methodologies biological matrices described terms extraction clean-up matrices. Detection systems with particular emphasis placed new developments screening technologies liquid chromatography fluorescence or mass spectrometry.