Estudo experimental da inibição da proliferação vitreorretiniana pelo uso da hiperecina

摘要: PURPOSE: To produce proliferative vitreoretinopathy (PVR) in an animal ocular trauma model. evaluate the inhibition of emergence and progression by hypericin. METHODS: Experimental Study. Nineteen pigmented male adult rabbits weighing between 2,000 3,000 grams were used this study. All them submitted to model with dispase retinal diathermy induce PVR membranes formation. They randomly assigned receive hypericin (10 µM 0.1 ml) or saline solution (0.1 as placebo. evaluated clinically seventh, fourteenth, twenty-first twenty-eighth postoperative days indirect ophthalmoscopy digital color retinography. The degree was classified according Hida (0 7). RESULTS: Membranes formation present 79% eyes; being 100% eyes placebo group 60% treatment (hypericin). comparison phases averages within groups showed a statistically significant difference two groups, p value 0.0321 for Wilcoxon test. CONCLUSIONS: produces vitreoretinal membranes. Hypericin considered effective decrease.