Virus Augmentation of The Antigenicity of Tumor Cell

作者: Faye C. Austin , Charles W. Boone

DOI: 10.1016/S0065-230X(08)60900-8

关键词: TransplantationImmunotherapyAntigenicityImmunologyBiologyImmunogenicityLytic cycleVirusImmune systemAntigen

摘要: Publisher Summary The membranes of tumor cells actively infected with the virus exhibit augmented immunogenicity. Many animal possess tumor-associated transplantation antigen (TATA) on their surface membrane; immunogenicity is lost when are disrupted. This chapter discusses enhanced cell extracts. Infection a lytic that induces viral cell-surface antigens augment TATA activity homogenate or oncolysate. mechanism augmentation operates through host's immune system. Positive results in immunoprophylaxis and immunotherapy virus-augmented model systems lead to initiation several attempts at human cancer patients. In addition, crude membrane extracts cultured elicit delayed hypersensitivity skin tests without any loss test specificity. virus-infected evaluated by studies, cancer, immunodiagnosis antigens.

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