Brain Tumor Therapy Using Genetically Engineered Replication-Competent Virus

摘要: Publisher Summary This chapter focuses on brain tumor therapy using genetically engineered replication-competent virus. The most malignant and fastest growing in the is glioblastoma multiforme. tumor, even with modern technology neurosurgical techniques, radiation, chemotherapy, allows a patient median survival of about one year after diagnosis. proposed therapeutic mechanisms involve either direct cell killing by virus or production new antigens surface to induce immunologic rejection. Viruses are efficient means for getting foreign genes into cells. Various preliminary studies have suggested that concept viral feasible because can be kill cells situ relative sparing surrounding brain. In multiforme, rapidly proliferating, whereas normal quiescent postmitotic. Therefore, provide selected target mutated replicate, lyse these cells, spread proliferating Many steps involved antitumor therapy: distinguishing between tissue abnormal .effective targeting elimination amplifying this effect discussion includes replication-incompetent vectors gene transfer tumors safety issues associated it. To overcome potential problems related therapy, other HSV mutants decreased neurovirulence also explored. Such mutant(s) would enable administration higher doses virus, rendering treatment more effective, example mutant RE6 R3616. Immune-mediated via delivery an active area research. Also, viruses described further produce cytokines increase therapy.