The effects of prophylactic cranial irradiation versus control on survival of patients with extensive-stage small-cell lung cancer: a meta-analysis of 14 trials
作者： Wei Ge , Huilin Xu , Yafei Yan , Dedong Cao
DOI: 10.1186/S13014-018-1101-3
关键词: Conventional PCI 、 Oncology 、 Hazard ratio 、 Subgroup analysis 、 Medicine 、 Relative risk 、 Internal medicine 、 Brain metastasis 、 Prophylactic cranial irradiation 、 Meta-analysis 、 Lung cancer
摘要: A recent Japanese study suggested prophylactic cranial irradiation (PCI) failed to improve survival of extensive-stage small-cell lung cancer (SCLC). However, previous studies showed that PCI was beneficial in reducing the rate mortality for SCLC. In this study, we aimed evaluate impact on patients diagnosed with SCLC by meta-analysis. PubMed, Embase, Cochrane library and Chinese Biomedical Literature database (CBM) were systematically searched identify eligible clinical assessing efficacy patients. After extracting data, brain metastasis, response rates, pooled estimates calculated. total 14 included, involving 1221 cases group 5074 control group. The results significantly improved overall (Hazard ratio (HR) = 0.57; 95% confidence interval (CI): 0.47, 0.69; p < 0.001) metastasis (risk (RR) =0.47, 95%CI: 0.33, p < 0.01). Subgroup analysis along sensitivity effects independent region, pre-PCI status administration timing. improves More randomized controlled trials are needed verify our findings.
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Guangming Tian, Jian Fang, Xiaoling Chen, Jun Nie, Jindi Han, Jie Zhang, Sen Han, Yang Wang, Di Wu, Ling Dai, Weiheng Hu, Xiangjuan Ma, Jieran Long, [Effects of Local Radiation Combined with Chemotherapy in the treatment of Patients with Extensive-stage Small Cell Lung Cancer]. Chinese Journal of Lung Cancer. ,vol. 18, pp. 272- 279 ,(2015) , 10.3779/J.ISSN.1009-3419.2015.05.04
Colin B. Begg, Madhuchhanda Mazumdar, Operating characteristics of a rank correlation test for publication bias. Biometrics. ,vol. 50, pp. 1088- 1101 ,(1994) , 10.2307/2533446
Paula R. Williamson, Catrin Tudur Smith, Jane L. Hutton, Anthony G. Marson, Aggregate data meta-analysis with time-to-event outcomes Statistics in Medicine. ,vol. 21, pp. 3337- 3351 ,(2002) , 10.1002/SIM.1303
Jan P van Meerbeeck, Dean A Fennell, Dirk KM De Ruysscher, Small-cell lung cancer The Lancet. ,vol. 378, pp. 1741- 1755 ,(2011) , 10.1016/S0140-6736(11)60165-7
Mahesh K. B. Parmar, Valter Torri, Lesley Stewart, Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine. ,vol. 17, pp. 2815- 2834 ,(1998) , 10.1002/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8
Cécile Le Péchoux, Ariane Dunant, Suresh Senan, Aaron Wolfson, Elisabeth Quoix, Corinne Faivre-Finn, Tudor Ciuleanu, Rodrigo Arriagada, Richard Jones, Rinus Wanders, Delphine Lerouge, Agnès Laplanche, Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a randomised clinical trial. Lancet Oncology. ,vol. 10, pp. 467- 474 ,(2009) , 10.1016/S1470-2045(09)70101-9
SE Schild, NR Foster, JP Meyers, HJ Ross, PJ Stella, YI Garces, KR Olivier, JR Molina, LR Past, AA Adjei, North Central Cancer Treatment Group, Prophylactic cranial irradiation in small-cell lung cancer: Findings from a North Central Cancer Treatment Group Pooled Analysis Annals of Oncology. ,vol. 23, pp. 2919- 2924 ,(2012) , 10.1093/ANNONC/MDS123
Ben Slotman, Corinne Faivre-Finn, Gijs Kramer, Elaine Rankin, Michael Snee, Matthew Hatton, Pieter Postmus, Laurence Collette, Elena Musat, Suresh Senan, Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer The New England Journal of Medicine. ,vol. 357, pp. 664- 672 ,(2007) , 10.1056/NEJMOA071780
William G. Rule, Nathan R. Foster, Jeffrey P. Meyers, Jonathan B. Ashman, Sujay A. Vora, Timothy F. Kozelsky, Yolanda I. Garces, James J. Urbanic, Joseph K. Salama, Steven E. Schild, Prophylactic cranial irradiation in elderly patients with small cell lung cancer: findings from a North Central Cancer Treatment Group pooled analysis. Journal of Geriatric Oncology. ,vol. 6, pp. 119- 126 ,(2015) , 10.1016/J.JGO.2014.11.002
M. Egger, G. D. Smith, M. Schneider, C. Minder, Bias in meta-analysis detected by a simple, graphical test BMJ. ,vol. 315, pp. 629- 634 ,(1997) , 10.1136/BMJ.315.7109.629