The Pharmacology and Immunopharmacology of Kinin Receptors

摘要: Publisher Summary This chapter discusses the kinin receptor agonists and antagonists, as well evidence for subtypes. The proinflammatory actions mediated by receptors and, in particular, critically analyzes important roles kinins inflammation. Kinins play a pivotal role pathophysiology of an inflammatory disease. It was only past decade or so that convincing emerged establishing most are via cell surface receptors. As consequence discovery potent, subtype-selective through cloning expression bradykinin (BK) genes, it is known at least two major G protein-coupled subtypes, B 1 2 , mediate kinins' actions. In considering range putative BK physiology pathophysiology, one may refer to exhaustive provocative recent review Stewart, which catalogs extensive list ranging topics like pain, inflammation, edema, shock, rhinitis, asthma. Some indications given types antagonist being used various sorts clinical trials. Peptide antagonists more likely be efficacious where they can applied locally; instance, treatment burn pain some neurogenic More stable nonpeptide administered systemically, acute otherwise fatal conditions, such shock edema.