Expression cloning of a human B1 bradykinin receptor.
作者： C D Strader , R W Ransom , T MacNeil , A W Derrick , J G Menke
DOI: 10.1016/S0021-9258(17)31844-6
关键词:
摘要: A cDNA clone encoding a human B1 bradykinin receptor was isolated from embryonic lung fibroblast library by expression cloning. The photoprotein aequorin utilized as an indicator of the ability agonist [des-Arg10]kallidin to mediate Ca2+ mobilization in Xenopus laevis oocytes injected with RNA. 1307-nucleotide insert which contains open reading frame 353-amino acid protein characteristics G-protein-coupled receptor. amino sequence is 36% identical B2 cloned expressed mammalian cells exhibits high affinity binding for 3H-labeled and low bradykinin. antagonist [des-Arg10,Leu9]kallidin effectively displaces receptor, whereas Hoe-140 (D-Arg0-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin, where Thi L-[3-(2-thienyl)alanyl], Tic D-(1,2,3,4-tetrahydroisoquinolin-3-yl-carbonyl), Oic L-[(3aS, 7aS)-octahydroindol-2-yl-carbonyl]) does not. Therefore, has pharmacological subtype. availability both receptors should allow elucidation relative contributions these two subtypes acute chronic inflammatory processes.
sci-hub.st 参考文章(40)
J Fraher, C D Strader, R W Ransom, T Macneil, J A Borkowski, J F Hess, G Y Stonesifer, Differential pharmacology of cloned human and mouse B2 bradykinin receptors. Molecular Pharmacology. ,vol. 45, pp. 1- 8 ,(1994)
S R Slivka, P A Insel, Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells. Evidence that bradykinin mediates noninterdependent activation of phospholipases A2 and C. Journal of Biological Chemistry. ,vol. 263, pp. 14640- 14647 ,(1988) , 10.1016/S0021-9258(18)68085-8
Y Kambayashi, S Bardhan, K Takahashi, S Tsuzuki, H Inui, T Hamakubo, T Inagami, Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. Journal of Biological Chemistry. ,vol. 268, pp. 24543- 24546 ,(1993) , 10.1016/S0021-9258(19)74499-8
M. Issandou, J.M. Darbon, Des-Arg9 bradykinin modulates DNA synthesis, phospholipase C, and protein kinase C in cultured mesangial cells. Distinction from effects of bradykinin. Journal of Biological Chemistry. ,vol. 266, pp. 21037- 21043 ,(1991) , 10.1016/S0021-9258(18)54817-1
M Mukoyama, M Nakajima, M Horiuchi, H Sasamura, R E Pratt, V J Dzau, Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. Journal of Biological Chemistry. ,vol. 268, pp. 24539- 24542 ,(1993) , 10.1016/S0021-9258(19)74498-6
Catherine D. Strader, Irving S. Sigal, Richard A. F. Dixon, Structural basis of beta-adrenergic receptor function. The FASEB Journal. ,vol. 3, pp. 1825- 1832 ,(1989) , 10.1096/FASEBJ.3.7.2541037
D. Gummelt, L. M. F. Leeb-Lundberg, M. M. Tropea, M. S. Herzig, B1 and B2 kinin receptors on cultured rabbit superior mesenteric artery smooth muscle cells: receptor-specific stimulation of inositol phosphate formation and arachidonic acid release by des-Arg9-bradykinin and bradykinin. Journal of Pharmacology and Experimental Therapeutics. ,vol. 264, pp. 930- 937 ,(1993)
Domenico C. Regoli, François Marceau, Jacques Lavigne, Induction of B1-receptors for kinins in the rabbit by a bacterial lipopolysaccharide European Journal of Pharmacology. ,vol. 71, pp. 105- 115 ,(1981) , 10.1016/0014-2999(81)90391-5
T. J. Murphy, R. Wayne Alexander, Kathy K. Griendling, Marschall S. Runge, Kenneth E. Bernstein, Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor Nature. ,vol. 351, pp. 233- 236 ,(1991) , 10.1038/351233A0
Nour-Eddine Rhaleb, Stéphane Dion, Jean Barabé, Noureddine Rouissi, Daniela Jukic, Guy Drapeau, Domenico Regoli, Receptors for kinins in isolated arterial vessels of dogs European Journal of Pharmacology. ,vol. 162, pp. 419- 427 ,(1989) , 10.1016/0014-2999(89)90332-4