Extracelluar matrix metalloproteinase as a novel target for pancreatic cancer therapy

作者: Sharon Samuel , Nemil Shah , Emily E. Helman , Joseph A. Knowles , Cecil R. Stockard

DOI: 10.1097/CAD.0B013E328349311E

关键词: MetalloproteinaseMatrix metalloproteinasePancreatic cancerRadioimmunoassayGene Knockdown TechniquesGene knockdownExtracellular matrixPancreatic tumorPathologyBiologyPharmacology (medical)Cancer researchOncologyPharmacology

摘要: The objective of this study was to evaluate extracellular matrix metalloproteinase (EMMPRIN) as a novel target in orthotopic pancreatic cancer murine models. MIA PaCa-2 human tumor cells were implanted groups 1 and 3–7, whereas EMMPRIN knockdown group

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